Keywords
final oocyte
How to Cite
Abstract
Study question: Does the use of dual triggering for final oocyte maturation improve reproductive outcomes in normal responders? Summary answer: Dual triggering resulted in a higher proportion of retrieved oocytes, MII oocytes per patient, and cryopreserved embryos for future transfers. What is already known: There are conflicting results regarding whether hCG + GnRH analogues increase the number MII oocytes and good embryos. Study design: Retrospective, case-control study. Study group of 54 patients and 108 in the control group. Study period from June 2021 to April 2024. Materials and Methods: Patients under 40 years of age who underwent ICSI with AMH [1.2–3.5] ng/ml and/or FSH <10 IU/ml were included. The study group underwent final oocyte maturation with hCG + GnRH analogue, and the control group with hCG. Patients were matched 2:1 with the study group to match age, final antral follicles, and gonadotropin doses used. Retrieved oocytes, MII, embryos obtained, goodquality embryos, clinical pregnancy per patient, implantation rate, and available cryopreserved embryos were analyzed. Averages, t-tests, Mann-Whitney tests, and chi-square tests were used. A p <0.05 was considered statistically significant. Results: The study group obtained a higher percentage of retrieved oocytes/final follicles (82% vs. 77% - p = 0.0027) and a higher number of MII oocytes (9.4 ± 4.2 vs.8.0 ± 4.2 - p = 0.0412). There were no differences in the number of embryos retrieved, embryos with Good morphology, and cumulative clinical pregnancy per patient (61% vs. 66% - NS). To achieve cumulative results, the Dual Trigger patients transferred fewer embryos (1.4 ± 0.5 vs. 1.7 ± 0.9 - NS), leaving 62% vs. 42% of the embryos retrieved available for future transfers (p < 0.0001). Implications of the findings: In line with previous studies, a higher rate of mature oocytes was found in dual trigger patients who responded normally. The higher proportion of cryopreserved embryos in the dual trigger group would allow for more opportunities for embryo transfers without performing a repeat ICSI.
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