Keywords
Endometrium
Instillation
How to Cite
Abstract
Study question: In patients with thin endometrium, refractory to usual hormonal treatments, could the use of autologous Platelet Rich Plasma, instilled in the uterine cavity, contribute as a synergistic factor in endometrial development?
Summary response: The use of endometrial Platelet Rich Plasma in this group of patients demonstrated a favorable effect in terms of increasing endometrial thickness and morphology.
What is already known: The thin endometrium, refractory to the usual hormonal treatments, is a challenge in medical treatment; Scientific evidence demonstrates a potential benefit of autologous Platelet Rich Plasma on the endometrium, with an effect in relation to the increase in endometrial thickness and / or changes that would favor correct embryo implantation.
Design: Retrospective observational pilot study, single group of 22 patients with thin endometrium refractory to usual hormonal treatments, with evaluation of paired samples from December 2018 to July 2020.
Materials and Methods: 22 patients were indicated for treatment with Rich Plasma in endometrial platelets due to a history of refractory thin endometrium in normal hormonal substituted cycles. Analysis of dichotomous and nominal quantitative and qualitative variables was use.
Results: The mean endometrial thickness prior to instillation was 5.9 mm (4.4 - 6.8 mm) and post-instillation was 7.2 mm (6.3-8.7 mm) trilaminar. The implantation rate was 63.63% (14 patients) and the clinical pregnancy rate 50% (11 patients).
Limitations: retrospective evaluations and use of other concomitant therapies, previously indicated by underlying causes of endometrial molecular studies.
Implication of the findings: Although there are few cases presented, this technique is seen as promising in this group of patients with thin endometrium, refractory to the usual treatments, being necessary to increase the casuistry and randomize groups of patients to evaluate if the trend is maintained.
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